Three Canadian-born players were selected on Day 2 of the 2021 NFL Draft.
- S JEVON HOLLAND (No. 36 overall, Miami) was born in Coquitlam, British Columbia, Canada.
- CB BENJAMIN ST-JUSTE (No. 74, Washington) was born in Montreal, Quebec, Canada.
- WR JOSH PALMER (No. 77, Los Angeles Chargers) was born in Brampton, Ontario, Canada.